Longitudinal data. Plot showing patients with longitudinal samples available. Circles represent RHP not showing any CHIP, whereas red squares represent RHP where CHIP was detected. Two patients (PT 14 and PT 16) who had no CHIP at the initial RHP were later found to harbor 1 CHIP (DNMT3A and ZRSR2, respectively). In contrast, no CHIP was found in the repeated RHP of the remaining 8 patients.