A total of 265 patients were approached for consent and 181 were enrolled; 47 patients were excluded because they declined consent. Thirty-six patients did not meet inclusion criteria. One patient voluntarily withdrew from the study. Of the enrolled patients, 63 were recruited from CH Clinic in the department of hematology (arm A) and 118 were recruited from elsewhere in the hospital system (arm B). Patients who were CH⁺ were defined as individuals with a CH variant present with a VAF of 2% or greater on the CHIVEseq assay (n = 99).