Figure 4.
Dynamic adaptation of BM niches supporting hematopoietic recovery after cytotoxic conditioning (chemotherapy or TBI). Cellular and molecular composition of BM niche signals supporting HSCs (black arrows) or other BM niches (blue arrows) during ablation, recovery, and return-to-equilibrium phases. Effects on BM niches are mentioned (sinusoidal-cell damage and neurotoxicity). BM niche populations are mentioned on the legend (lower panel). a7R, alpha-7 nicotinic receptor; cOPN, cleaved osteopontin; FGF1, fibroblast growth factor 1; GM-CSF, granulocyte-macrophage colony-stimulating factor; Jag1, jagged-1; mTNF-α, membrane bound tumor necrosis factor α; NGF, nerve growth factor; PTN, pleiotrophin; SCF, stem cell factor; THPO, thrombopoietin; TNFR, TNF receptor.

Dynamic adaptation of BM niches supporting hematopoietic recovery after cytotoxic conditioning (chemotherapy or TBI). Cellular and molecular composition of BM niche signals supporting HSCs (black arrows) or other BM niches (blue arrows) during ablation, recovery, and return-to-equilibrium phases. Effects on BM niches are mentioned (sinusoidal-cell damage and neurotoxicity). BM niche populations are mentioned on the legend (lower panel). a7R, alpha-7 nicotinic receptor; cOPN, cleaved osteopontin; FGF1, fibroblast growth factor 1; GM-CSF, granulocyte-macrophage colony-stimulating factor; Jag1, jagged-1; mTNF-α, membrane bound tumor necrosis factor α; NGF, nerve growth factor; PTN, pleiotrophin; SCF, stem cell factor; THPO, thrombopoietin; TNFR, TNF receptor.

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