Overview of subtypes and genetic-risk group in BCP-LBL. (A) Comparison of frequencies of subtypes in BCP-LBL compared with published data from Brady et al,⁷ showing a largely similar distribution. (B) Confusion matrix showing a high degree of concordance between the subtypes assigned based on aneuploidies, gene fusions, and SNVs (reference, columns) and subtypes predicted using the ALLCatchR classifier (rows), which is solely based on gene expression data. (C) Bar graph showing for each of the subtypes, the sensitivity and specificity of the ALLCatchR prediction. (D) Distribution of subtypes associated with risk for BCP-LBL based on known risk-associated subtypes in BCP-ALL. (E) Cumulative incidence of relapse in the BCP-LBL cohort based on genetic-risk groups known from BCP-ALL, comparing high-risk and nonhigh-risk genetic subtypes. Outcome or follow-up data was missing for 20 patients.