Figure 3.
Overview of recurrently mutated genes and pathways in BCP-LBL. Oncoplot showing recurrently mutated and deleted genes in our BCP-LBL cohort based on single-nucleotide variants and small indels. Mutated genes were divided into functional categories, as indicated on the left of the figure. For 80 patients, mutational data was derived from WES analysis (data type, WES). The analysis of the WES data was limited to a selection of 536 genes with known oncogenic potential (see “Methods”). For 13 additional patients, mutational data was derived from the analysis of a limited set of lymphoma-related genes (in black in the gene list) covered by the EuroClonality-NDC capture assay (data type: Euroclonality panel). For samples in gray, focal deletions could not be determined.