Figure 2.
Pyk2 silencing decreases MM tumor growth in a mouse xenograft model. (C) SCID/Beige mice were injected IV with GFP+/Luc+-MM.1S Pyk2-knockdown (A4) or FAK-knockdown cells (3 × 106/mouse) to establish an MM xenograft model (n = 5 per group). Tumor burden was detected and quantified using BLI. Inhibition of Pyk2 significantly reduced MM tumor burden compared with scramble control. One mouse in the day 26 FAK-K.D. image was excluded from the analysis due to poor IV injection of luciferin for that mouse.
