CUT&Tag analysis of YY1 and SMC3 binding sites. (A) Heat map of SMC3 and YY1 signals around SMC3 peak summits at different genomic regions. Each row represents a SMC3 peak region that is defined as a 1-kilobase genomic region flanking a SMC3 CUT&Tag peak summit. (B) YY1, SMC3, and cobinding peak numbers. (C) Percentages and numbers of YY1 and SMC3 cobinding peaks at different genomic regions. (D) Top 10 overrepresented GO terms on genes that have proximal promoters occupied with SMC3 and YY1 peaks. (E) In total, 27% of SMC3 binding peaks were lost upon YY1 knockdown. (F) Top 10 overrepresented GO terms on genes that have lost SMC3 bindings at proximal promoters upon YY1 knockdown.