ChIP-seq analysis of YY1 and cohesin complex protein binding sites. (A) Heat map of SMC3, CTCF, SMC1, and YY1 ChIP-seq signals around SMC3 peak summits. Each row represents a SMC3 peak region that is defined as a 500-bp genomic region flanking a SMC3 ChIP-seq peak summit. (B) Venn diagrams to compare the overlapping of CTCF, SMC1, and YY1 peaks with that of SMC3 peaks. (C-D) Top 10 overrepresented GO terms on genes that have proximal promoters overlapping with SMC3 peaks. Genes were stratified by the 471 SMC3 peaks overlapping with SMC1 and CTCF but not YY1 (C), and the 409 SMC3 peaks overlapping with SMC1, CTCF, and YY1 (D).