Validation of prognostically relevant cell-cell interactions in independent single-cell sequencing cohorts. (A) Diagram. (B-D) Venn diagrams showing overlap between interactions identified in TTPlow/TTPhigh patients of our cohort with published cohorts using single-cell RNA-seq. (E-F) Examples of dual interactions that were detected with statistically significance in our cohort and published cohorts using single-cell RNA-seq. CS Memory B cells, class-switched memory B cells.