Correlation of genomic events to the disease stage. (A) Forest plot showing the association between individual genes alteration and clinical stage of MF divided into LR and HR, as depicted by OR. (B-E) Kaplan-Meier plots of individual genetic factors predictive of OS in univariate and multivariate models of 48 patients with a newly diagnosed MF: del10p11.22 (B); gain of 10p15.1 (C); gain of 7q (D); and del6q16.3 (E). (F) Kaplan-Meier curves for analysis of time to progression in patients with LR disease. P values were derived from log-rank test. (G) CD25 immunohistochemistry at diagnosis of MF skin biopsies in patients with gain of 10p15.1 (top panels, MF sample of patient 18 and patient 14 with presence of transformed MF cells) or without gain of 10p15.1 (bottom panels, MF sample of patient 23 and patient 16). Scale bars indicate 150 μm.