Effect of FXIIa inhibition on contact pathway–initiated TG in PK-sufficient and -deficient WB. Representative curves of silica-initiated TG in Klkb1^+/+ (A) and Klkb1^–/– (B) mouse WB in the presence of increasing concentrations of the inhibitory anti-FXIIa antibody garadacimab. Quantification of TG lag time (C) and peak TG (D) in Klkb1^+/+ or Klkb1^–/– mouse WB in the presence of 50 μg/mL garadacimab or IgG control (n = 3-5 per group). Data presented as individual values with mean ± SD. Data analyzed with paired Student t tests comparing samples with and without inhibitor; ∗∗P < .01. Gara, garadacimab; ns, not signficant.