Figure 6.
Genetic inhibition of P-selectin attenuates lung injury in MDS mice. (A) Schematic of the experimental procedure. (B) Confirmation of P-selectin knockdown in PB platelets from RUNX1S291fs/HMGA2 mice. (C) Schematic of the experimental procedure for intranasal LPS administration. (D) Gross morphology of lung from indicated mice after low-dose LPS administration. Representative gross morphology is shown. Scale bar indicates 10 mm. (E-F) H&E staining of a lung section from RUNX1S291fs/HMGA2 mice with or without Selp knocked down after low-dose LPS administration (n = 6 per each group). Scale bars: left panels, 250 μm (original magnification ×40); middle panels, 50 μm (original magnification ×100); and right panels, 25 μm (original magnification ×400). Lung injury score of individual samples is shown in panel F. More than 10 random high-power fields were scored. Data are presented as the mean ± SD. ∗∗P < .01.

Genetic inhibition of P-selectin attenuates lung injury in MDS mice. (A) Schematic of the experimental procedure. (B) Confirmation of P-selectin knockdown in PB platelets from RUNX1S291fs/HMGA2 mice. (C) Schematic of the experimental procedure for intranasal LPS administration. (D) Gross morphology of lung from indicated mice after low-dose LPS administration. Representative gross morphology is shown. Scale bar indicates 10 mm. (E-F) H&E staining of a lung section from RUNX1S291fs/HMGA2 mice with or without Selp knocked down after low-dose LPS administration (n = 6 per each group). Scale bars: left panels, 250 μm (original magnification ×40); middle panels, 50 μm (original magnification ×100); and right panels, 25 μm (original magnification ×400). Lung injury score of individual samples is shown in panel F. More than 10 random high-power fields were scored. Data are presented as the mean ± SD. ∗∗P < .01.

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