Inflammatory markers, impaired renal function, and imaging studies in iMCD-TAFRO. Plasma levels of (A) CRP (reference, <0.5 mg/dL), (B) ferritin (reference, 13-150 ng/mL), and (C) creatinine (reference, 0.5-1.2 mg/dL) are associated with a flare. Timeline for the administration of medications (rituximab, sirolimus, siltuximab, cyclosporine, and methylprednisolone) is indicated. (D) Coronal CT image showing (a) hepatosplenomegaly (red double arrow). Other panels (b-e) are axial images of the chest, abdomen, and pelvis. (b) Multiple enlarged mediastinal lymph nodes (yellow arrows). (c) Volume overload with diffuse anasarca and moderate volume ascites (blue arrows) with enlarged para-aortic lymph node (yellow arrow). (d) Mild dilatation of the main pulmonary artery (green double arrow), and adenopathy (yellow arrows). (e) Periportal edema (blue arrow) and wedge-shaped hypodensity in the posterior aspect of the spleen, concerning for small infarcts (red arrowhead).