Figure 3.
CD3ζ truncCAR-integration facilitates CAR expression in different nonconventional T-cell subtypes and NK cells. (A) HLA-A2 CAR-integration in regulatory T-cells, n = 3 biological replicates. (B) CD19-CAR integration in TCRγ/δ T cells. TRAC integration generates CAR+/TCRγ/δ+ double positive T cells, n = 2 biological replicates. (C) Integration of a CD19-CAR in primary human NK cells, n = 6 biological replicates.

CD3ζ truncCAR-integration facilitates CAR expression in different nonconventional T-cell subtypes and NK cells. (A) HLA-A2 CAR-integration in regulatory T-cells, n = 3 biological replicates. (B) CD19-CAR integration in TCRγ/δ T cells. TRAC integration generates CAR+/TCRγ/δ+ double positive T cells, n = 2 biological replicates. (C) Integration of a CD19-CAR in primary human NK cells, n = 6 biological replicates.

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