PD parameters. (A) Mean (95% CI) serum-free complement C5 concentration over time. (B) Mean (95% CI) cRBC hemolysis over time. The graph presents values before ravulizumab (lower values) and after ravulizumab (higher values) dosing at every visit for each patient subgroup. Dashed horizontal lines indicate 0.5 μg/mL (A) and 20% hemolysis (B), the thresholds for complete C5 inhibition. BL, baseline; cRBC, chicken red blood cells.