Baseline MTV estimates from whole-body FDG PET images. Single-slice coronal FDG PET images (A,E) demonstrating hypermetabolic uptake in the original image data sets. (A-D) Hypermetabolic FDG uptake in a limited number of lesions in the abdomen and pelvis with an estimated total whole-body MTV of 231.9 mL. (E-H) Hypermetabolic FDG uptake in soft-tissue and nodal lesions in the chest and abdomen with an estimated total whole-body MTV of 1921.7 mL. The segmented lesions containing the individual lesion masks (colored regions in panels B,F) are shown. Within each of these segmented lesions, masks of the FDG PET voxels with SUV values 41% to 100% of SUVmax are delineated on the parametric maps (C,G). The total whole-body MTV is then calculated from the sum of delineated voxels. The arrows represent normal physiologic activity in the bladder (A,E) and gastrointestinal tract (A). Panels D,H are maximum intensity projection images that represent the extent of disease on the whole-body FDG PET.