Figure 1. Mechanisms of T-cell and... | American Society of Hematology

Figure 1.

Mechanisms of T-cell and neutrophil interactions. (A) DC differentiation72,73 (activation). (B) DC recruitment72,74 (activation). (C) Antigen donation from neutrophils to DCs75,76 (activation). (D) NETosis induces Th17 differentiation9,77 (activation). (E) T-cell priming of Th1 and Th17 T cells9,78,79 (activation). (F) Inhibitory cytokine release80-83 (suppression). (G) TCRζ downregulation84-87 (suppression). (H) Treg enhancement88,89 (suppression). (I) DC suppression11,90 (suppression). (J) T-cell exhaustion91,92 (suppression). Cathelicidin’s impact on the Th17/Th1 balance has only been demonstrated in mouse cells as of 2024 and is therefore labeled “mouse only.” IL-10, interleukin-10; NET, neutrophil extracellular trap; TGFβ, transforming growth factor beta; Th, T helper cell; TCR, T-cell receptor; DC, dendritic cell. Figure made with Biorender.com.

Mechanisms of T-cell and neutrophil interactions. (A) DC differentiation⁷²^,⁷³ (activation). (B) DC recruitment⁷²^,⁷⁴ (activation). (C) Antigen donation from neutrophils to DCs⁷⁵^,⁷⁶ (activation). (D) NETosis induces Th17 differentiation⁹^,⁷⁷ (activation). (E) T-cell priming of Th1 and Th17 T cells⁹^,⁷⁸^,⁷⁹ (activation). (F) Inhibitory cytokine release^80-83 (suppression). (G) TCRζ downregulation^84-87 (suppression). (H) Treg enhancement⁸⁸^,⁸⁹ (suppression). (I) DC suppression¹¹^,⁹⁰ (suppression). (J) T-cell exhaustion⁹¹^,⁹² (suppression). Cathelicidin’s impact on the Th17/Th1 balance has only been demonstrated in mouse cells as of 2024 and is therefore labeled “mouse only.” IL-10, interleukin-10; NET, neutrophil extracellular trap; TGFβ, transforming growth factor beta; Th, T helper cell; TCR, T-cell receptor; DC, dendritic cell. Figure made with Biorender.com.

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