Summary of the mouse model developed by Klein et al. The STAT5B^N642H mutation, found in the indicated human cancers, is expressed in the NK-cell lineage, leading to a chronic NK-cell lymphoproliferation and progressing over time to ANKL in a subset of the mice. EATL, enteropathy-associated T-cell lymphoma; HSTCL, hepatosplenic T-cell lymphoma; T-ALL, T-cell acute lymphoblastic leukemia; T-LGLL, T-cell large granular lymphocytic leukemia; T-PLL, T-cell prolymphocytic leukemia; γδ TCL, γδ T-cell lymphoma. Figure created with BioRender.com.