Effect of ECP therapy on frequency of cell populations. (A) Representative dot plot and statistical analysis of components of CD4+ and CD8+CAR-T cells with respect to effector (E; CCR7-CD45RA+), naive (N; CCR7+CD45RA+), central memory (CM; CCR7+CD45RA–), and effector memory (EM; CCR7-CD45RA-) subsets. (B) Workflow of data mining algorithm. (C) t-SNE plot of Phenograph identified cell clusters. Evaluation of distinguishing capability of cell clusters by principal component analysis (PCA) (D) and hierarchical cluster (E). (F) Identification of cell clusters by significance analysis. (G-N) t-SNE plot and statistical analysis of cell clusters. Samples of 4 individual donors were tested. A 2-tailed t test was used for statistical analysis. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001.

Effect of ECP therapy on frequency of cell populations. (A) Representative dot plot and statistical analysis of components of CD4+ and CD8+CAR-T cells with respect to effector (E; CCR7-CD45RA+), naive (N; CCR7+CD45RA+), central memory (CM; CCR7+CD45RA–), and effector memory (EM; CCR7-CD45RA-) subsets. (B) Workflow of data mining algorithm. (C) t-SNE plot of Phenograph identified cell clusters. Evaluation of distinguishing capability of cell clusters by principal component analysis (PCA) (D) and hierarchical cluster (E). (F) Identification of cell clusters by significance analysis. (G-N) t-SNE plot and statistical analysis of cell clusters. Samples of 4 individual donors were tested. A 2-tailed t test was used for statistical analysis. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001.

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