Prognostic impact of mutations detected by BMPC and ctDNA analyses. (A-B) Kaplan-Meier survival curves of PFS of 259 RRMM cases with and without (A) KRAS and (B) TP53 mutation detected by ctDNA-seq. (C-D) Kaplan-Meier survival curves of PFS of 161 RRMM cases (having both BMPC-seq and ctDNA-seq data) without and with (C) KRAS mutation and (D) TP53 alteration present in only BMPC, only ctDNA, and both. (E) Total number of mutated genes in the 6 prognostically significant genes (KRAS, TP53, DIS3, BRAF, NRAS, and ATM) detected by ctDNA-seq in 259 RRMM cases. (F) Kaplan-Meier survival curves of PFS of 259 RRMM cases stratified by the total number of mutated genes in the 6 prognostically significant genes. Log-rank test.