Risk of VTE according to genotype in 938 355 individuals. Effect size estimates, 95% CI, and 2-sided P values obtained using a random-effects meta-analysis (N = 938 355) are shown. The third and fourth columns display the number of VTE cases and controls stratified by genotype carrier status. For each comparison, the adjusted OR and 95% CI are plotted. Noncarriers of both FVL and PTGM were set as the reference group (OR = 1.0).