Outcome by randomization arm. (A) CIR by randomization arm: at 4 years, CIR was estimated at 13.2% (95% CI, 6.7%-21.9%) in arm A vs 30.7% (95% CI, 20.8%-41.2%) in arm B (P = .017). (B) NRM by randomization arm: at 4 years, NRM was estimated at 10.6% (95% CI, 4.9%-18.8%) in arm A vs 11.4% (95% CI, 5.6%-19.6%) in arm B (P = .88). (C) OS by randomization arm: at 4 years, OS was estimated at 79.4% (95% CI, 70.6%-89.3%) in arm A vs 73.4% (95% CI, 63.9%-84.4%) in arm B (P = .27). (D) RFS by randomization arm: at 4 years, RFS was estimated at 76.2% (95% CI, 67.2%-86.4%) in arm A vs 58.5% (95% CI, 48.4%-70.7%) in arm A (P = .029).