Schematic summary of Hoxa9/β-catenin/Prmt1-mediated regulation of HSC quiescence and DNA replication dynamics. (Top panel) The maintenance of HSC functionality in the absence of either Hoxa9 or β-catenin. (Bottom panel) The perturbance to qHSC and aHSC equilibrium and DNA replication dynamics induced by coinactivation of Hoxa9 and β-catenin.