Pharmacogenomic investigation identified compounds that could specifically target the KISS-high myeloblasts. (A) Kinase inhibitors were positively enriched at the top of the compound list ordered by the Pearson correlation coefficients between the KISS and drug sensitivity. (B) Pearson correlation of the KISS and drug sensitivity; a positive Pearson correlation coefficient implies that a compound is more effective against the KISS-high AML cell lines. (C) The correlation between axitinib sensitivity and KISS. (D) The correlation between taselisib sensitivity and KISS. NES, net enrichment score.