Functional analysis of KISS-high vs KISS-low patients with MDS. (A) Heat map illustrating the most significant DE genes (25 most upregulated and 25 most downregulated genes). (B) The LSC17 genes were significantly upregulated in the KISS-high subgroup. (C) GSEA highlighted the enrichment of HSC and LSC-associated gene sets in the KISS-high subgroup. GSEA, gene set enrichment analysis.