TKI sensitivity of transduced Ba/F3 cell lines expressing ABL-class fusions. (A) Dose-response curves of transduced Ba/F3 cell lines with various ABL-class fusions for imatinib. (B) Bar graph of half-maximal inhibitory concentration (IC50) values of imatinib obtained from dose-response curves. (C) Dose-response curves of transduced Ba/F3 cell lines with various ABL-class fusions of dasatinib. (D) Bar graph of IC50 values of dasatinib obtained from dose-response curves. (E) Dose-response curves of transduced Ba/F3 cell lines with various ABL-class fusions for bosutinib. (F) Bar graph of IC50 values of bosutinib obtained from dose-response curves. For the dose-response curves, the values are normalized against untreated controls for each cell line and represent the mean ± SEM (n = 3). Bar graphs represent the mean ± SEM.
