Comparison of sample characteristics with sensitivity to imatinib. (A) Box plots of diagnostic and relapse samples and Z-score of the area under the dose-response curve (AUC). (B) Box plots of primary ALL samples, primary xenograft ALL samples, and serial PDX-transplanted ALL samples and the Z-score of the AUC for imatinib. The mean AUC of imatinib was compared using the Kruskal-Wallis test with Dunn post hoc test. (C) Box plots of ALL cells from B-lineage (indicated by “B”) or T-lineage (indicated by “T”) and the Z-score of the AUC for imatinib. The box plots show the median Z-score ± 1.5× interquartile range in the Tukey style. The red dots represent patient 2, from whom ALL cells were obtained from day 33 after 2 weeks of TKI treatment.