Ex vivo TKI sensitivity per ABL-class tyrosine kinase gene colored by the 5′ fusion partner. (A) Dose-response curves for imatinib treatment of ZMIZ1::ABL1- (dark blue), NUP214::ABL1- (medium blue), or RCSD1::ABL1-fused (light blue) primary or primary xenografted ALL samples. (B) Dose-response curves for imatinib in primary or primary xenografted ALL samples with EBF1::PDGFRB fusion (pink) or other PDGFRB fusions (purple), JAKMIP2, or CCDC88C). Leukemic cell survival relative to untreated controls, mean ± standard error of the mean (SEM) of 1 to 3 biological replicates.