Macrovascular (A) vs microvascular (B) thrombosis. VWF (blue fibrils) is comparatively enriched in the microvascular thrombus, whereas fibrin (orange fibrils) is relatively enriched in the large-vessel thrombus. Products of thrombus degradation are depicted on the right (downstream blood flow) of each image. In the case of large-vessel thrombi, these consist mostly of fibrin degradation products (orange) and ADAMTS13 degradation products of VWF. In the case of microvascular thrombi, degradation products are enriched in plasmin-derived VWF degradation products (cVWF) relative to fibrin degradation products and VWF polypeptides derived from ADAMTS13 cleavage of VWF. Figure courtesy of Paresh Kulkarni.