Kogler et al suggest that lipid metabolite content, particularly deacetylated lysophosphatidylcholine (LPC-O), could be used as a screening and sorting test for platelets to be stored at either room temperature storage (22°C; RSPs) or cold storage (4°C; CSPs), paving the way for a personalized medicine approach to platelet use. Potential concerns with this approach include increased cost to blood centers and increased inflammatory response with higher LPC-O. The debate over circulation time (RSPs) vs hemostatic function (CSPs) remains unresolved until clinical trial data are available.