Favorable PK profile and effective target cell clearance by CD33/CD123 NANOBODY TCE in cynomolgous monkeys. A single dose CD33/CD123-TCE was administered at 0.4 or 0.04 μg/kg (2 animals per dose level). (A) Exposure of the NANOBODY compound was measured in plasma over time to determine half-life T_1/2 (days) shown to the right. (B) Using flow cytometry, CD123+ cells, CD14+ monocytes (C), and CD3+ T cell counts (D) were determined in peripheral blood at the indicated time points. Individual animal values are shown.