Light microscopy images of EBV+ nPTCL. Hematoxylin and eosin staining and EBV-encoded small RNA (EBER) ISH were performed to examine nuclear morphology, revealing a (A) centroblastoid (UPN857) or (B) pleomorphic appearance (UPN317). (C-D) Tumor cells are positive for EBER (C, UPN857; D, UPN317). Scale bar, 50 μm.