Top gene candidates from ElasticNet analysis distinguishing response groups. ElasticNet heat map for baseline expressed genes in MYD88-mutated patients with WM who received ibrutinib monotherapy on a clinical trial, and who attained a major response (green) or no major response (gray) at 6 months. The heat map shows the scaled VST gene expression levels selected by ElasticNet, which best predicts differences observed in response between the 2 groups. Each patient’s CXCR4 mutation status is shown above the heat map. FS, frameshift mutation; NS, nonsense mutation; VST, variance stabilizing transformation; WT, wild type.