Compositional and differential changes over time. (A) Principal component ordinate analysis at baseline (day 1), day 7, day 14, and day 28 by donor (blue points) and recipient (red points). Blue square shape represents the median of the Euclidean distances for donor, and the red square shape represents median of the Euclidean distances for recipients. The red circle and blue circle showing 95% confidence interval based on the t-distribution of the Euclidean distance for donor and recipient respectively. R² and P values derived using Adonis2 test are annotated for each day. (B) Bray-Curtis distances over the first 28 days from FMT with respect to average taxonomic composition of the 4 donor samples. Each line indicates individual participant’s beta diversity distance with respect to donor. Participant number labels indicate the last available data point for that participant. (C) Species shown to be significantly differentially abundant between baseline and day 7 or day 14 or day 28 with AncomBC analysis. Circles at day and species indicate the log fold change. Dotted line separates the days before and after FMT. Double dotted line with vertical gap separates the origins of species based on the fecal microbiome survey at baseline for recipient and donors. All species have adjusted P values <.05, minimum prevalence of 50% across all samples, and minimum absolute log fold change >1.