Associations of TML with TTFT among full cohort and stratified by CLL-IPI. (A) Cumulative incidence plot of progression to first treatment among individuals with either HCMBL or CLL by TML. (B) Cumulative incidence plot of progression to first treatment among individuals with HCMBL or CLL by TML among low-risk CLL-IPI. (C) Cumulative incidence plot of progression to first treatment among individuals with HCMBL or CLL by TML among intermediate-risk CLL-IPI. (D) Cumulative incidence plot of progression to first treatment among individuals with HCMBL or CLL by TML among high-risk or very high–risk CLL-IPI. TML is the number of genes out of 59 with high-impact mutations (excluding TP53). CIF Est, cumulative incidence function estimation.