Associations of TML with TTFT among individuals with HCMBL. (A) Cumulative incidence plot of progression to first treatment among individuals with HCMBL. (B) Cumulative incidence plot of progression to first treatment among individuals with HCMBL by TML. TML is the number of genes out of 59 with high-impact mutations (excluding TP53). CIF Est, cumulative incidence function estimation.