Gene frequencies and TML distribution between HCMBL and CLL. (A) Scatterplot of the frequency of mutated genes found in HCMBL and CLL. Red dotted line represents equal mutated gene frequency. (B) Distribution of the TML score between individuals with CLL and HCMBL. (C) Distribution of mutation type between individuals with HCMBL and patients with CLL with Rai stage 0. TML is the number of genes out of 59 with high-impact mutations (excluding TP53).