cHSPCs are preactivated and represent a quick response progenitor population, contributing to extramedullary hematopoiesis. They are enriched for multilymphoid progenitors, which are transcriptionally programmed to preferentially migrate to the thymus. Furthermore, cHSPCs can reenter the bone marrow, potentially contributing to clonal redistribution. Additionally, cHSPCs could have a use as biomarkers of the bone marrow composition in hematopoietic pathologies. cMLP, circulating multilymphoid progenitor.