Crystal structure of the BCL2 G101V mutant in complex with sonrotoclax. (A) Comparison of the structures of WT BCL2 (yellow) and the G101V mutant (gray) in complex with sonrotoclax. (B-C) Conformational changes of residues around G/V101 in the crystal structures of WT BCL2 and G101V in complex with venetoclax (B) and sonrotoclax (C). The complex structures of BCL2:venetoclax (PDB ID: 6O0K) and BCL2 G101V:venetoclax (PDB ID: 6O0L) are shown in cyan and light orange, respectively. The minimum distances between E152 of the BCL2 G101V mutant and the compounds are indicated by green and red dashed lines.