Intratumoral T cells enhance NK-cell–mediated RTX efficacy. (A-C) Mice were inoculated with luciferase-expressing Raji-Luc cells mixed with PBMCs containing varying percentages of T cells, on day 0. Weekly treatment with RTX or TRA was started on day 7. (A) Spider plot of total flux determined using bioluminescent imaging. (B) Changes in tumor flux after treatment compared with that of before treatment (day 21 vs day 4). (C) Kaplan-Meier curve of survival. Mice were euthanized when tumors exceeded 20 mm in any dimension. (D) In a separate experiment, mice were inoculated with Raji-Luc mixed with either PBMCs or CD56-depleted PBMCs on day 0, followed by weekly RTX treatment starting on day 7. Bioluminescent imaging was used to determine changes in tumor flux after treatment compared with before treatment (day 21 vs day 4).