Figure 2. Adjusting T-cell numbers in... | American Society of Hematology

Figure 2.

$Adjusting T-cell numbers in the inoculum results in varying T-cell numbers in the emerging tumors but does not have a detectable impact on fractions of malignant cells or NK cells. (A) Schematic diagram of a humanized mouse model in which mice were inoculated on day 0 with consistent numbers of Raji tumor cells and T-cell–depleted PBMCs but varying numbers of T cells. (B) Flow cytometric analysis of FNAs obtained from mouse xenografts 20 days after inoculation and evaluated for percent of cells that are CD19+, CD56+, or CD3+ (n = 12-15 mice per group).$

Adjusting T-cell numbers in the inoculum results in varying T-cell numbers in the emerging tumors but does not have a detectable impact on fractions of malignant cells or NK cells. (A) Schematic diagram of a humanized mouse model in which mice were inoculated on day 0 with consistent numbers of Raji tumor cells and T-cell–depleted PBMCs but varying numbers of T cells. (B) Flow cytometric analysis of FNAs obtained from mouse xenografts 20 days after inoculation and evaluated for percent of cells that are CD19⁺, CD56⁺, or CD3⁺ (n = 12-15 mice per group).

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