Time required to restore ADAMTS13 activity since PEX start according to treatments. Patients were grouped according to treatments received. (A,C,E) Kaplan-Meier curves were constructed considering the time elapsed since PEX start and the time required to achieve ADAMTS13 activity ≥20%, and the log-rank test was applied for comparisons between treatment schemes. Those patients whose ADAMTS13 levels were below 20% by the end of the study were censored at the date of the last test and are indicated in the curves. (B,D,F) The number of days from PEX start to ADAMTS13 recovery >20% were also compared between treatment schemes. Those patients who did not recover ADAMTS13 activity by the end of the study were not considered. Capla, caplacizumab.