Lower tumor volume, high C_max, and high naïve CD8⁺ T cells at baseline were associated with prolonged PFS. (A) PFS by percentage of naïve CD8⁺ T cells. (B) DOR by percentage of naïve CD8⁺ T cells. Significant associations between naïve CD8⁺ cells and DOR (P = .044) and PFS (P = .014) were observed when using median (2.14%) as cutoff (data not shown). A cutoff (3.5%) at which most separation between PFS and DOR was derived, and results are shown here. (C) PFS by tumor volume and C_max. (D) PFS by TMTV and percentage of naïve CD8⁺ T cells. (E) Naïve CD8⁺ T cells by tumor volume and C_max. CD, cluster of differentiation; NA, not available; TV, tumor volume.