Roles of miR-145 in cancer, arterial cardiovascular diseases, and VTE. miR-145 regulates tumor growth, angiogenesis, apoptosis, tumor invasion, and metastasis in various cancers. miR-145 affects cells involved in various arterial cardiovascular diseases: smooth muscle cells, endothelial cells, fibroblasts, and cardiomyocytes. miR-145 is now also shown to be protective against VTE, possibly because of its relationship with tissue factor, coagulation factor XI, plasminogen activator inhibitor-1, and platelets.^1,6-10