Incidence, severity, and LGI involvement of flares. (A) The cumulative incidence of flares after CR/VGPR; the cumulative incidence at 6 month was 21.6% (95% CI, 19.0-24.2). (B) The proportion of grades 3/4 acute GVHD at first onset in the entire population (n = 968, 16.3%), in patients with flare (n = 210, 18.1%), and at the time of flare (n = 210, 41.4%). (C) The proportion of LGI involvement at first onset in the entire population (n = 968, 31.6%), in patients with flare (n = 210, 32.9%), and at the time of flare (n = 210, 55.2%). P values for pairwise comparisons were adjusted using a Bonferroni method. The error bars represent standard error.