Patients with severe ICAHT show poor survival outcomes. (A-B) Kaplan-Meier estimates of PFS (A) and OS (B) comparing patients with grade 3-4 ICAHT (red) vs absent or grade 1-2 ICAHT (green). The P value of the log-rank test is shown on the bottom right of the graph. The median PFS and OS in months and HR of the univariate Cox regression model are superimposed above each graph. (C-D) Subgroup analysis of PFS (C) and OS (D) stratified by 3 ICAHT severity groups. Absent hematotoxicity (grade 0, blue) was compared with mild-to-moderate (grade 1-2, dark green) and severe-to-life-threatening ICAHT (grade 3-4, yellow). The P value of the log-rank test and the HRs using absent ICAHT (grade 0) as the reference are depicted.