SE induce drug resistance in purified malignant T-cell cultures via JAK-dependent or -independent mechanisms. (A) Flow cytometric plot showing percentage of malignant T cells before and after sorting of PBMCs from SS4. (B-C) Flow cytometric plots showing percentage of viable malignant cells from sorted malignant T cells treated with 2 nM romidepsin for 72 hours in the presence or absence of SE and JAK inhibitor (1 μM tofacitinib) of patient exhibiting JAK-independent (SS13) (B) and JAK-dependent (SS4) (C) resistance being induced by the presence of SE. DMSO, dimethyl sulfoxide.