Forest plots and regional association plots for 2 variants with time-dependent genetic effects for platelet count during pregnancy. Forest plots showing the genetic effect of rs12041331-G allele at 1q23.1 (PEAR1) (A) and rs12276986-T allele at 11q23.3 (CBL) (B) on meta-analysis for platelet count during the first, second, and third trimester, at delivery, and during the postpartum period. Points represent genetic effect (β). Hollow points indicate a P value not reaching genome-wide significance (P = 5 × 10–8). The error bars indicate the 95% CI of β. Regional association plots from top to bottom represent the results of meta-analyses for platelet count during the first, second, and third trimesters at 1q23.1 (PEAR1) (C) and 11q23.3 (CBL) (D). The x-axis shows the chromosomal positions (GRCh38), and the y-axis indicates –log10(P value) for the association tests. The purple diamond indicates the lead SNP of each locus. The other SNPs are colored based on their LD r2 with the lead SNP. The dashed gray line represents the genome-wide significance threshold for GWAS (P = 5 × 10–8). The gene track highlighted in red shows the nearest gene for the lead SNP.
