Manhattan plots of the genome-wide association study meta-analyses for platelet counts during the first, second, and third trimesters. A total of 72 816 Chinese pregnant women with at least 1 platelet count in each trimester from 2 hospitals were included in the GWAS meta-analyses. The Manhattan plots depict GWAS meta-analyses of platelet counts during the first trimester (A), the second trimester (B), and the third trimester (C). GWAS for each hospital was carried out with a linear regression model, and the 1st to 10th principal components, maternal age, and gestation age correspond to the time of the platelet count test as covariates. The x-axis shows the ordered chromosomes, and the y-axis indicates –log10(P value) for the association tests. The dashed black line represents the genome-wide significance threshold for GWAS (P = 5 × 10–8). A total of 138 genome-wide significant independent loci (161 independent signals) achieved the genome-wide significance threshold. Labels in black indicate the nearest gene of the novel loci, and labels in red highlight the 2 loci (PEAR1 and CBL) with time-dependent genetic effects during pregnancy.
