Levels of LDH and hemoglobin over time during management of the acute BTH event with intensive pegcetacoplan treatment. (A) LDH level on log 10 scale. (B) Hemoglobin level. In cases of multiple acute BTH events, data relate to first acute BTH event reported. All local laboratory values were standardized to a central laboratory based on normal ranges from respective laboratories. ∗Most recent available measurement before intensive pegcetacoplan treatment. ^†Dependent on available measurement 7 to 12 days and 14 to 19 days after intensive pegcetacoplan treatment, respectively. ^‡Patients receiving transfusions during management of acute BTH. Hb, hemoglobin; LDH, lactate dehydrogenase; LLN, lower limit of normal; PEG, pegcetacoplan; ULN, upper limit of normal.